Interrelationship of superficial siderosis and microbleeds in cerebral amyloid angiopathy

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Superficial siderosis in cerebral amyloid angiopathy

With great interest, we read the recent review article by Kumar entitled “Neuroimaging in Superficial Siderosis: An In-Depth Look,” published on-line ahead of print in the American Journal of Neuroradiology in September 2009. The author provides a thorough review of neuroimaging in superficial siderosis (SS) of the central nervous system and details important underlying causes of this phenomeno...

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Cerebral amyloid angiopathy, hemorrhages and superficial siderosis.

See related article, pages 2894–2897. In this issue of Stroke, Feldman and coworkers1 describe 3 subjects with clinically somewhat atypical Alzheimer Disease (AD) and with a radiologically verified superficial siderosis (SS). In 2 of these patients, a neuropathological examination confirmed AD with concomitant cerebral amyloid angiopathy (CAA) and a premortem diagnosis of SS. Thus, a linkage wa...

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Cortical superficial siderosis and first-ever cerebral hemorrhage in cerebral amyloid angiopathy.

OBJECTIVE To investigate whether cortical superficial siderosis (cSS) is associated with increased risk of future first-ever symptomatic lobar intracerebral hemorrhage (ICH) in patients with cerebral amyloid angiopathy (CAA) presenting with neurologic symptoms and without ICH. METHODS Consecutive patients meeting modified Boston criteria for probable CAA in the absence of ICH from a single-ce...

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Prevalence and mechanisms of cortical superficial siderosis in cerebral amyloid angiopathy.

OBJECTIVE We investigated the prevalence and clinical-radiologic associations of cortical superficial siderosis (cSS) in patients with probable cerebral amyloid angiopathy (CAA) compared to those with intracerebral hemorrhage (ICH) not attributed to CAA. METHODS We conducted a retrospective multicenter cohort study of 120 patients with probable CAA and 2 comparison groups: 67 patients with ei...

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Recurrent Subarachnoid Bleeding and Superficial Siderosis in a Patient with Histopathologically Proven Cerebral Amyloid Angiopathy

A 68-year-old man with a history of hypertension presented with recurrent subarachnoid bleeding. Brain MRI showed superficial siderosis, and diagnostic cerebral angiograms did not show any intracranial vascular malformation or arterial aneurism. Post mortem neuropathological examination of the brain was consistent with a diagnosis of cerebral amyloid angiopathy. Clinicians should be aware that ...

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ژورنال

عنوان ژورنال: Neurology

سال: 2014

ISSN: 0028-3878,1526-632X

DOI: 10.1212/wnl.0000000000000984